I just got into using UV, and I needed to onboard a few projects. UV recently changed how it uses virtual environments.

• Create pyproject.toml if it does not exist.

uv init

• Create the virtual environment

uv venv

• Activate the virtual environment. This is not needed if uv venv was created without overriding the default name. Then, using uv run ... automatically detects the virtual environment.

source .venv/bin/activate

• Install dependencies

uv sync

• Move dependencies defined in requirements.txt into pyproject.toml

uv add -r requirements.txt

• Run the script

uv run .\file.py